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KMID : 0365919950310060015
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Journal of the Pusan Medical Association
1995 Volume.31 No. 6 p.15 ~ p.22
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Results of Radiotherapy in Early Cervical Cancer (Stage I, IIA)
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Cho Hyang-Suk
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Abstract
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Purpose:
@EN The aim of this study is to analyze the survival rate and complication in early cervical cancer(stage I, IIa0 treated with radiation therapy alone.
@ES Materials and methods:
@EN Among 189 patients treated with radiation therapy alone in early cervical cancer(stage I, IIa) at Kosin Medical Center between January, 1980 and December, 1986, 166 patients except follow up loss of 23 patient were retrospectively analyzed.
Age
distribution was 28-73 years(mean: 54.3 years). Stage distribution by FIGO staging system was 38 patients(22.9%, stage Ia: 2 patients, stage Ib: 36 patients) in stage I and 128 patients(77.1%) in stage IIa. The most common histologic type was
squamous
cell carcinoma(163 patient, 98.2%). Positive pelvic lymph node metastasis at initial diagnosis was 2 patients(5.3%) in stage I and 8 patients(6.3%) in stage IIa. Radiation therapy used 4-6MV linear accelerator with conventional technique
(180-200Gy/fr.)
was done by total pelvis with intracavitary radiotherapy with Cs-137(130 patients, 78.3%) and total pelvis with small field radiotherapy (36 patients, 21.7%). Total dose distribution of radiation was 60-96Gy(mean: 65Gy) in stage I and
64-98Gy(mean:
75Gy) in stage IIa. Duration of follow up was 60-108 months (mean: 94 months). Local control classified complete response, partial response and no response or stable.
@ES Results:
@EN Overall local control rate was 96.4%(stage I: 97.4%, stage IIa: 96.1%) in complete response, and overall 5 year survival rate was 97% in stage I and 89% in stage IIa. There were no statistically differences in 5 year survival rates by total
doses of
radiation, treatment modality and initial lymph node metastasis. Among 25 patients(15.1%) had have treatment failure, 16 patients(64%) were local failure and 8 patients(32%) were distant metastasis, and common sites of distant metastasis were
paraaortic
and/or supraclavicular nodes(8 patients). Complication had experience in 20 patients(12%), among them, 4 patients(10.5%) were in stage I and 16 patients(12.5%) were in stage IIa, and common complication was rectal bleeding and/or stenosis(7
patients)
@ES Conclusion:
@EN From this study we found that survival rate by radiation therapy alone in early cervical cancer (stage I, IIa) was similar to reports of others(Table 7, 13).
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